Christian Grimm Selected Research

Retinal Degeneration

12/2022	Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones.
1/2020	PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration.
1/2019	Correction to: Retinal Degenerative Diseases.
1/2019	Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
12/2018	Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.
1/2017	Digoxin-induced retinal degeneration depends on rhodopsin.
1/2016	The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors.
11/2015	Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.
1/2013	CDC42 is required for tissue lamination and cell survival in the mouse retina.
8/2012	Transcorneal electrical stimulation shows neuroprotective effects in retinas of light-exposed rats.

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Christian Grimm Research Topics

Disease

26	Retinal Degeneration 12/2022 - 03/2002
20	Hypoxia (Hypoxemia) 03/2022 - 07/2002
13	Neoplasms (Cancer) 01/2022 - 07/2008
8	Macular Degeneration (Age-Related Maculopathy) 01/2019 - 09/2012
5	Retinal Diseases 07/2022 - 06/2000
5	Mucolipidoses (Sialidosis) 01/2021 - 11/2009
5	Inflammation (Inflammations) 01/2020 - 01/2017
4	Infections 01/2021 - 02/2015
4	Edema (Dropsy) 10/2020 - 04/2008
3	Retinitis Pigmentosa (Pigmentary Retinopathy) 12/2022 - 10/2008
3	Ischemia 10/2020 - 01/2006
3	Atrophy 01/2020 - 04/2009
3	Gliosis 10/2019 - 04/2008
3	Optic Neuritis (Retrobulbar Neuritis) 10/2019 - 01/2018
2	Emphysema 01/2022 - 01/2022
2	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 07/2008
2	Obesity 01/2021 - 01/2017
2	Melanoma (Melanoma, Malignant) 01/2021 - 01/2021
2	Disease Progression 11/2019 - 09/2012
2	Retrograde Degeneration 10/2019 - 01/2019
2	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2017
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2018 - 09/2012
2	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 08/2015 - 01/2008
2	Glaucoma 08/2015 - 09/2012
2	Pain (Aches) 01/2014 - 05/2011
2	Retinopathy of Prematurity (Retrolental Fibroplasia) 09/2012 - 09/2005
2	Hypertrophy 08/2008 - 04/2008
2	Hearing Loss (Hearing Impairment) 12/2007 - 06/2007
1	Color Vision Defects (Color Blindness) 07/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 07/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022
1	Lung Injury 01/2022
1	Lung Diseases (Lung Disease) 01/2022
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2022
1	Glioblastoma (Glioblastoma Multiforme) 01/2021
1	Breast Neoplasms (Breast Cancer) 01/2021
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2021
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2021
1	Choroidal Neovascularization 01/2021
1	Virus Diseases (Viral Diseases) 12/2020
1	Plague (Bubonic Plague) 08/2020
1	Epidemic Louse-Borne Typhus (Typhus) 08/2020
1	Communicable Diseases (Infectious Diseases) 08/2020
1	Cholera 08/2020
1	Anaphylaxis (Anaphylactic Shock) 01/2020
1	Body Weight (Weight, Body) 01/2020

Drug/Important Bio-Agent (IBA)

31	Retinaldehyde (Retinal)IBA 12/2022 - 06/2000
13	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2006
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2006
11	CationsIBA 01/2022 - 01/2017
5	Oxygen (Dioxygen)IBA 01/2022 - 01/2011
5	Two-Pore ChannelsIBA 01/2021 - 08/2014
4	Ion Channels (Ion Channel)IBA 01/2021 - 12/2007
4	Bacterial ToxinsIBA 01/2021 - 01/2017
4	CholesterolIBA 01/2021 - 08/2014
4	Pharmaceutical PreparationsIBA 12/2020 - 05/2011
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 07/2002
4	Erythropoietin FDA Link 01/2012 - 07/2002
4	Leukemia Inhibitory FactorIBA 01/2011 - 12/2008
3	LipidsIBA 03/2022 - 01/2018
3	CytokinesIBA 01/2020 - 11/2006
2	SmokeIBA 01/2022 - 01/2022
2	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2019
2	EnzymesIBA 01/2021 - 02/2008
2	tetrandrineIBA 01/2021 - 02/2015
2	Cholera ToxinIBA 01/2021 - 10/2017
2	ChemokinesIBA 01/2020 - 07/2008
2	LigandsIBA 11/2019 - 11/2015
2	ProteomeIBA 01/2019 - 01/2018
2	LDL CholesterolIBA 11/2017 - 10/2017
2	Rhodopsin (Visual Purple)IBA 01/2017 - 12/2006
2	Calcitonin Receptor-Like ProteinIBA 08/2015 - 01/2008
2	Protein Isoforms (Isoforms)IBA 08/2014 - 12/2007
2	Aryldialkylphosphatase (Paraoxonase)IBA 10/2013 - 02/2008
2	DNA (Deoxyribonucleic Acid)IBA 04/2010 - 07/2008
2	Neuroprotective AgentsIBA 06/2009 - 01/2006
2	Glial Fibrillary Acidic ProteinIBA 08/2008 - 04/2008
2	AdrenomedullinIBA 02/2008 - 01/2008
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 07/2002 - 03/2002
1	RNA (Ribonucleic Acid)IBA 12/2022
1	Histone DemethylasesIBA 07/2022
1	Histones (Histone)IBA 07/2022
1	GSK-J4IBA 07/2022
1	Pancreatic Elastase (Elastase)IBA 01/2022
1	Matrix Metalloproteinase 12IBA 01/2022
1	Glycoproteins (Glycoprotein)IBA 01/2022
1	Glucagon (Glukagon)FDA Link 01/2021
1	FlavonoidsIBA 01/2021
1	Melanins (Melanin)IBA 01/2021
1	Monophenol Monooxygenase (Tyrosinase)IBA 01/2021
1	Microphthalmia-Associated Transcription FactorIBA 01/2021
1	Peptide Hydrolases (Proteases)FDA Link 10/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2020
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2020
1	Progesterone FDA LinkGeneric 01/2020
1	Granzymes (Granzyme)IBA 01/2020

Therapy/Procedure

9	Therapeutics 07/2022 - 06/2007
2	Lasers (Laser) 01/2021 - 12/2009
2	Immunotherapy 01/2020 - 07/2008
1	Lung Transplantation 10/2020